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  • Title: Synergistic effect of zinc nanoparticles and temperature on acute toxicity with response to biochemical markers and histopathological attributes in fish.
    Author: Kumar N, Chandan NK, Wakchaure GC, Singh NP.
    Journal: Comp Biochem Physiol C Toxicol Pharmacol; 2020 Mar; 229():108678. PubMed ID: 31783177.
    Abstract:
    In the present study, an experiment was carried out to delineate the lethal concentration of (LC50) zinc nanoparticles (Zn-NPs) alone and with concurrent to high temperature (34 °C) in Pangasianodon hypophthalmus. The lethal concentration of Zn-NPs alone and with high temperature was estimated as 21.89 and 19.74 mg/L respectivey in P. hypophthalmus. The lethal concentration was decided with the help of definite concentration via 16, 18, 20, 22, 24, 26, 28 and 30 mg/L. The Zn-NPs were significantly alter the biochemical and histopathology of different fish tissues. The stress biomarkers such as oxidative stress (catalase superoxide dismutase and glutathione-s-transferase, lipid peroxidation) was studied in the liver, gill and kidney tissue, which was noticeable (p < 0.01) enhanced with higher concentration in both condition (Zn-NPs alone and Zn-NPs-T) in dose dependent manners. The carbohydrate (lactate dehydrogenase and malate dehydrogenase) and protein metabolic enzymes (alanine amino transferase and aspartate amino transferase) were also remarkable enhanced (p < 0.01) with higher concentration of Zn-NPs and Zn-NPs-T. The neurotransmitter (acetylcholine esterase) activities were significant inhibited (p < 0.01) with exposure to Zn-NPs and Zn-NPs-T and digestive enzymes such as protease and amylase were non-significant (p > 0.01) with the exposure of Zn-NPs and Zn-NPs-T, further, lipase were significantly reduced (p < 0.01) with exposure to Zn-NPs and temperature exposure group. The histopathological alteration were also observed in the liver and gill tissue. The present investigation suggested that, essential trace elements at higher concentration in acute exposure led to pronounced deleterious alteration on histopathology and cellular and metabolic activities in fish.
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