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  • Title: Detection of severe hypertension in a patient with neurofibromatosis type 1 during anesthesia induction: a case report.
    Author: Wang J, Wei G, Wang Z, Huang H.
    Journal: J Med Case Rep; 2019 Nov 30; 13(1):349. PubMed ID: 31783902.
    Abstract:
    BACKGROUND: Neurofibromatosis type 1 has a higher prevalence of pheochromocytoma and paraganglioma than the general population: 1.0-5.7% versus 0.2-0.6%. Currently, there are no generally accepted guidelines for screening for pheochromocytoma and paragangliomas in asymptomatic patients with neurofibromatosis type 1. CASE PRESENTATION: Severe hypertension developed during anesthesia induction in our patient, a 44-year-old Chinese man with neurofibromatosis type 1. We screened for catecholamine level after glioma resection, and the patient was diagnosed with combined pheochromocytoma and paraganglioma. CONCLUSIONS: A delay in diagnosis or lack of a diagnosis in pheochromocytoma and paraganglioma may increase the perioperative morbidity and mortality risk due to excess catecholamine secretion. Therefore, routine pheochromocytoma and paraganglioma screening preoperatively in patients with neurofibromatosis type 1 is very important.
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