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  • Title: ALK-negative anaplastic large cell lymphoma with "Hodgkin-like" cytomorphology and nuclear expression of PAX5.
    Author: Fratoni S, Niscola P, Zhao XF, Larocca LM, Capalbo A, Fabbretti M, Bernardini L, Abruzzese E.
    Journal: Pathol Res Pract; 2020 Feb; 216(2):152724. PubMed ID: 31784094.
    Abstract:
    Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking "Hodgkin-like" cytomorphology and a very uncommon nuclear expression of PAX5.
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