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  • Title: Effect of dietary n-3 polyunsaturated rich fish oil supplementation on ovarian function and interferon stimulated genes in the repeat breeding cow.
    Author: Teeli AS, Sheikh PA, Patra MK, Singh D, Kumar B, Kumar H, Singh SK, Verma MR, Krishnaswamy N.
    Journal: Anim Reprod Sci; 2019 Dec; 211():106230. PubMed ID: 31785633.
    Abstract:
    Dietary n-3 polyunsaturated fatty acids (n-3 PUFA) improve utero-ovarian functions and embryonic survival in postpartum dairy cows. Because early embryonic mortality is the major cause of repeat breeding (RB) in cows, there was investigation of the effect of dietary supplementation of n-3 PUFA [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] rich fish oil (FO) from -2 to +2 weeks of artificial insemination on the size of preovulatory follicle (POF), serum progesterone (P4) and relative abundance of the mRNA of interferon stimulated genes (ISG) that encode for these proteins in the peripheral blood leukocytes (PBL) in the RB cow (n = 12). The diet of control group was supplemented with palm oil (PO). The results indicated serum concentrations of EPA and DHA were greater by 4.6- and 3.5-fold, respectively at the end of feeding study in the RB cows of the FO group. The diameter of POF was larger by 2.2 mm in FO group; however, serum P4 did not vary from day 14-20 post-artificial insemination. Greater abundance of ISG mRNA transcripts such as ISG15, RTP4, Mx2 and OAS1 in the PBL of pregnant cows of FO group indicates day 20 conceptuses produced more IFN-τ. It is concluded that supplementation of FO during the breeding period increased the size of POF and enhanced the abundance of ISG mRNA transcripts in RB cows that became pregnant.
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