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  • Title: Genotyping of Human Papillomavirus in Cervical Squamous Intraepithelial Lesions in Mexican Women.
    Author: Colín-Ferreyra MDC, Domínguez-García MV, Mendieta-Zerón H, Camarillo-Romero MDS, Pérez-Rogel M, Martínez-Madrigal M, Martínez-Pérez S, Romero-Figueroa MDS.
    Journal: Jpn J Infect Dis; 2020 Mar 24; 73(2):157-160. PubMed ID: 31787740.
    Abstract:
    Approximately 40 genotypes of the human papillomavirus (HPV) have been identified in cervical mucosa. In particular, HPV-16 and HPV-18 have been associated with cervical neoplasia. Squamous intraepithelial lesions (SILs) are precursors of cervical cancer. This study aimed to identify the HPV by genotype in SILs using a linear array genotyping test in a population in Mexico. We performed a cross-sectional study of 129 female patients with or without SILs, as determined by colposcopy, who completed a risk factor questionnaire. Cervical swab samples were obtained and genotyped using a Linear Array HPV Genotyping assay. Forty-nine (37.98%) samples were positive for HPV, and 24 genotypes were identified among these samples. The most common genotype was HPV-16. Twelve genotypes were found in both high- and low-grade SILs (HPV-6, 16, 31, 39, 51, 52, 53, 58, 59, 61, 67, and 84), of which seven were high-risk SILs (HPV-16, 31, 39, 51, 52, 58, and 59). Among the populations studied, the most frequent genotype was HPV-16, multiple infections were found, and four patients without injury tested positive for HPV.
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