These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The calcium channel antagonist omega-conotoxin inhibits secretion from peptidergic nerve terminals.
    Author: Dayanithi G, Martin-Moutot N, Barlier S, Colin DA, Kretz-Zaepfel M, Couraud F, Nordmann JJ.
    Journal: Biochem Biophys Res Commun; 1988 Oct 14; 156(1):255-62. PubMed ID: 3178834.
    Abstract:
    The binding of omega-conotoxin to isolated rat neurohypophysial nerve terminals, its effect on the depolarization-induced increase of cytoplasmic Ca2+ and on the potassium and electrically-induced release of vasopressin (AVP) have been studied. The results show that isolated neurosecretory nerve endings have calcium channels with a high affinity for omega-CgTx and that this toxin inhibits neurohormone release at very low concentration (IC50 = 0. 1nM). Although secretion of vasopressin is inhibited to a great extent by the toxin it is shown that a small but significant amount of the depolarization-induced AVP release is insensitive to omega-CgTx and to the dihydropyridine molecule nicardipine.
    [Abstract] [Full Text] [Related] [New Search]