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  • Title: Effect of n-butyrate on the synthesis of sulfated glycosaminoglycans and hyaluronate by rat liver fat-storing cells (Ito cells).
    Author: Gressner AM, Haarmann R.
    Journal: Biochem Pharmacol; 1988 Oct 01; 37(19):3771-6. PubMed ID: 3178890.
    Abstract:
    The effect of naturally occurring aliphatic carboxylic acid n-butyrate on total and type-specific synthesis of sulfated proteoglycans and hyaluronic acid by rat liver fat-storing cells (Ito cells, vitamin A-storing cells), the main connective tissue producing cell type in liver, was studied. Concentrations of n-butyrate equal to and higher than 5 mM inhibited significantly in a dose-dependent manner the incorporation of [35S]sulfate and [3H]glucosamine into the carbohydrate chains of sulfated proteoglycans. Maximum inhibition of 70% was reached at 15 mM. Similarly, the formation of hyaluronic acid was impaired by n-butyrate. The synthesis profile of specific sulfated proteoglycans was not affected by the compound. beta-Xyloside, an artificial carbohydrate chain initiator, reversed only partially the inhibitory effect of n-butyrate. Thus, the mechanism of n-butyrate inhibition may involve an impairment of both proteoglycan core protein formation and glycosaminoglycan chain elongation.
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