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  • Title: [ADP-ribosylation of nuclear proteins in the rat brain].
    Author: Zaalishvili TM, Kolkhidashvili KM, Margiani DO, Michilashvili RD.
    Journal: Biokhimiia; 1988 Jun; 53(6):931-5. PubMed ID: 3179353.
    Abstract:
    The distribution of (ADP-ribose)n synthesized from [14C]NAD labeled at the adenyl ring in several protein fractions of isolated rat brain nuclei was studied. Preferential ADP-ribosylation of nonhistone nuclear proteins was shown to occur. It was demonstrated that pol (ADP-ribose)polymerase and DNA-topoisomerase II are located spatially close to each other. A correlation between ADP-ribosylation and the activity of nuclear matrix DNA-topoisomerase II was established.
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