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  • Title: Photoelectric Cardiac Pacing by Flexible and Degradable Amorphous Si Radial Junction Stimulators.
    Author: Liu Z, Wen B, Cao L, Zhang S, Lei Y, Zhao G, Chen L, Wang J, Shi Y, Xu J, Pan X, Yu L.
    Journal: Adv Healthc Mater; 2020 Jan; 9(1):e1901342. PubMed ID: 31794161.
    Abstract:
    Implanted pacemakers are usually bulky and rigid electronics that are constraint by limited battery lifetimes, and need to be installed and repaired via surgeries that risk secondary infection and injury. In this work, a flexible self-powered photoelectric cardiac stimulator is demonstrated based on hydrogenated amorphous Si (a-Si:H) radial p-i-n junctions (RJs), constructed upon standing Si nanowires grown directly on aluminum thin foils. The flexible RJ stimulators, with an open-circuit voltage of 0.67 V and short-circuit current density of 12.7 mA cm-2 under standard AM1.5G illumination, can be conformally attached to the uneven tissue surface to pace heart-beating under modulated 650 nm laser illumination. In vivo pacing evaluations on porcine hearts show that the heart rate can be effectively controlled by the external photoelectric stimulations, to increase from the normal rate of 101-128 beating min-1 . Importantly, the a-Si:H RJ units are highly biofriendly and biodegradable, with tunable lifetimes in phosphate-buffered saline environment controlled by surface coating and passivation, catering to the needs of short term or lasting cardiac pacing applications. This implantable a-Si:H RJ photoelectric stimulation strategy has the potential to establish eventually a self-powered, biocompatible, and conformable cardiac pacing technology for clinical therapy.
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