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  • Title: The median preoptic nucleus participates in the control of paraventricular vasopressin neurons by the subfornical organ in the rat.
    Author: Tanaka J, Saito H, Seto K.
    Journal: Brain Res; 1988 Oct 04; 461(2):403-6. PubMed ID: 3179725.
    Abstract:
    Extracellular single-unit activity was recorded from phasically firing neurohypophyseal neurons (n = 41) in the hypothalamic paraventricular nucleus (PVN) of urethane-anesthetized male rats. Electrical stimulation of the subfornical organ (SFO) produced orthodromic long-duration (n = 18) or short-duration (n = 10) excitation or inhibition (n = 8) of the activity of PVN neurons. The long-duration excitatory response of about half (n = 7) the neurons (n = 15) tested was reversibly abolished by microinjection of the local anesthetic lidocaine into the median preoptic nucleus (MnPO), whereas neither the short-duration excitatory (n = 7) nor inhibitory (n = 6) responses were affected. These results suggest that the SFO efferents through the MnPO to the PVN may transmit the neuromodulatory signals which evoke long-duration increases in the excitability of putative vasopressin (VP)-secreting neurons in the PVN.
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