These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry.
    Author: Noguchi K, Morita Y, Kiyama H, Ono K, Tohyama M.
    Journal: Brain Res; 1988 Aug; 464(1):31-5. PubMed ID: 3179743.
    Abstract:
    Using in situ hybridization histochemistry, we examined the biosynthesis of the preprotachykinin-A (PPTA) mRNAs, which code for substance P (SP) and also a related peptide, substance K (SK), in the rat dorsal root ganglion (DRG). The animals were injected with a small amount of formalin in the right hindpaw for nociceptive chemical stimulation. Analysis of hybridization signals in the emulsion autoradiography showed that the lumbar-5 DRG neurons expressing PPTA mRNAs were significantly increased in number and signal intensity on the formalin-injected side. Such elevation of the PPTA mRNA expression in the DRG was observed as early as 3 h after formalin injection. These results show that the expression of the PPTA gene is activated by chemogenic noxious stimuli.
    [Abstract] [Full Text] [Related] [New Search]