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  • Title: Trisomy and tetrasomy of the long arm of chromosome 1 in a direct preparation of human endometrial adenocarcinoma.
    Author: Horgas G, Grubisić G, Spaventi S.
    Journal: Cancer Genet Cytogenet; 1988 Oct 15; 35(2):269-72. PubMed ID: 3180026.
    Abstract:
    Chromosome banding analysis was performed on an endometrial adenocarcinoma. A minimal variety in the chromosome number and morphology was found. All analyzed pseudodiploid and aneuploid carcinoma cells had two chromosomes 1 of normal morphology and the presence of a marker or markers derived from chromosome 1. Tetrasomy of the long arm of chromosome 1 was found in 12 of 19 cells analyzed, accompanied by trisomy of the long arm of chromosome 1 in the rest of the cells. No other common chromosome marker was observed. Previously published data and our results suggest that trisomy and tetrasomy of the long arm of chromosome 1 may represent a specific karyotypic change in subtypes of endometrial adenocarcinoma.
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