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  • Title: Single-dose prophylaxis with cefotetan in elective abdominal surgery. A controlled trial.
    Author: Gruwez JA, Lerut J, Christiaens MR, De Roose J, Vernimmen L, Hendrickx J, Trimpeneers F, Schroé H, Deruyter M, Williams KJ.
    Journal: Chemioterapia; 1988 Aug; 7(4):218-22. PubMed ID: 3180299.
    Abstract:
    Single dose cefotetan was compared with either a combination of metronidazole and cefazolin given for 24 hours or 3 doses of cefuroxime as prophylaxis in elective abdominal surgery. Wound infections and infections at remote sites (UTI and RTI) were similar in all groups. In a third group prophylaxis of abdominal surgery using a single 2g dose of cefotetan was compared to 2 doses of the same drug, given 12 hours apart. There was no demonstrable advantage to giving 2 doses. The low incidence of post-operative infections seen in all groups indicates the efficacy of cefotetan in the surgical prophylaxis of elective abdominal surgery.
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