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  • Title: A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status.
    Author: Jun YW, Hebenbrock M, Kool ET.
    Journal: Chem Commun (Camb); 2019 Dec 19; 56(2):317-320. PubMed ID: 31808778.
    Abstract:
    Abnormal vitamin B6 status, marked by deficient intracellular concentrations of pyridoxal phosphate (PLP), is classified as a direct biomarker based on its biomedical significance. However, there exist no direct methods for measuring vitamin B6 status in intact cells. Here we describe the development of a fluorogenic probe, RAB6, which shows remarkable selectivity for PLP among the B6 vitamers and other cellular aldehydes.
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