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  • Title: Clinical Implications of Claudin18.2 Expression in Patients With Gastric Cancer.
    Author: Baek JH, Park DJ, Kim GY, Cheon J, Kang BW, Cha HJ, Kim JG.
    Journal: Anticancer Res; 2019 Dec; 39(12):6973-6979. PubMed ID: 31810969.
    Abstract:
    BACKGROUND/AIM: Claudin18.2 (CLDN18.2) is a tight junction protein that has been identified as a promising target in gastric cancer. This study aimed to evaluate the clinical relevance of CLDN18.2 expression in gastric cancer. PATIENTS AND METHODS: This study included 367 patients diagnosed with gastric cancer, who underwent curative surgical resection. Immunohistochemical staining for CLDN18.2 was carried out, and expression was scored semi-quantitatively, based on staining intensity and the percentage of staining. RESULTS: CLDN18.2 expression was observed in 273 patients (74.4%), and 108 (29.4%) were classified as CLDN18.2-positive by predefined criteria. CLDN18.2 expression was not correlated with age, sex, tumor location, or stage. Expression rates were higher in diffuse-type and HER2-positive tumors. In multivariate survival analysis, CLDN18.2 expression was not associated with survival outcomes. CONCLUSION: Higher expression of CLDN18.2 was observed in diffuse-type and HER2-positive gastric cancers. Meanwhile, CLDN18.2 expression was not associated with survival in patients with gastric cancer.
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