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  • Title: Rifampicin-isoniazid and delayed elimination of theophylline: a case report.
    Author: Dal Negro R, Turco P, Trevisan F, De Conti F.
    Journal: Int J Clin Pharmacol Res; 1988; 8(4):275-7. PubMed ID: 3182118.
    Abstract:
    This paper reports a case of tuberculosis relapse and chronic obstructive lung disease treated with rifampicin and isoniazid. The subsequent introduction of slow-release theophylline therapy revealed a delay in the theophylline elimination kinetics resulting in a toxic plasma level. Interference with hepatic microsomal enzymes is considered to occur.
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