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  • Title: Ki-67 labeling index and the grading of cerebral gliomas by using intravoxel incoherent motion diffusion-weighted imaging and three-dimensional arterial spin labeling magnetic resonance imaging.
    Author: Wang C, Dong H.
    Journal: Acta Radiol; 2020 Aug; 61(8):1057-1063. PubMed ID: 31830431.
    Abstract:
    BACKGROUND: Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional arterial spin labeling (3D-ASL) have been applied to brain tumors; however, the relationship between their parameters and the Ki-67 labeling index (Ki-67 LI) for the grading of gliomas have yet to be investigated. PURPOSE: The aim of this study is to compare multiple parameters obtained from IVIM-DWI and 3D-ASL with the Ki-67 LI when grading gliomas. MATERIAL AND METHODS: Fifty-two patients with pathologically confirmed gliomas had undergone magnetic resonance imaging (MRI), including IVIM-DWI and 3D-ASL imaging. Mann-Whitney U tests were conducted and receiver operating characteristic (ROC) curves were generated to determine parameters for distinguishing high-grade gliomas (HGGs) from low-grade gliomas (LGGs). These parameters included the apparent diffusion coefficient (ADC), true diffusivity (D), pseudo diffusivity (D*), perfusion fraction (f), cerebral blood flow (CBF), and their relative values (rADC, rD, rD*, rf, and rCBF). Spearman correlation analysis was used to assess the correlations of the parameters of MRI with the Ki-67 LI. RESULTS: The rADC, rD, and rf were significantly lower in HGGs than in LGGs (P < 0.005 for all). The rD had a significantly greater area under the ROC curve than that of the other parameters in the differentiation of HGGs from LGGs (P < 0.05). Both the rD and rf were moderately negatively correlated with the Ki-67 LI. CONCLUSION: Both the rD and rf can be used for the quantitative prediction of the Ki-67 LI. Among the extracted parameters, the rD had the significantly greatest diagnostic efficacy.
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