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  • Title: ASSESSMENT OF RADIOPROTECTIVE ACTION OF BASIDIOMYCOTIC MELANIN PIGMENTS ON THE HEMATOPOIETIC SYSTEM OF Balb/C MICE UNDER EXPOSURE TO IONIZING RADIATION IN SUBLETHAL DOSE.
    Author: Bilko DI, Russu IZ, Bilko NM.
    Journal: Probl Radiac Med Radiobiol; 2019 Dec; 24():210-219. PubMed ID: 31841468.
    Abstract:
    OBJECTIVE: Assessment of radioprotective action of basidiomycotic melanin pigments on hematopoietic stem and progenitor bone marrow cells of Balb/C mice in case of exposure to ionizing radiation in sublethal dose. MATERIALS AND METHODS: Using original method of cultivation in gel diffusion chambers in vivo of bone marrow cells of Balb/C mice we investigated the colony-forming efficiency of hematopoietic progenitor cells of the ani- mals, which were exposed to ionizing radiation action in sublethal dose, in case of treatment with melanin pig- ments solution of basidiomycotic fungi as radioprotector. RESULTS AND CONCLUSIONS: Investigation of functional activity of bone marrow progenitor cells of Balb/C mice allowed assessing their hematopoiesis state in case of ionizing radiation action, as well as in case of previous treat- ment of the animals with the solution of melanin pigments as radioprotector. It was determined that under the influence of ionizing radiation the colony-forming activity of mice bone marrow has decreased comparing to con- trol. Solution of melanin pigments was able to enhance the functional activity of bone marrow of irradiated ani- mals. Obtained results of radioprotective action of basidiomycotic melanin pigments solution on irradiated stem cells and their descendants (progenitor cells) may become the evidence for development of the protective means for human organism from the injuring action of ionizing radiation. Meta: otsinka radioprotektornoï diï melaninovykh pigmentiv bazydiomitsetiv na krovotvorni stovburovi klityny ta klityny-poperednyky kistkovogo mozku myshey̆ Balb/C u razi vplyvu ionizuiuchoï radiatsiï v subletal'niy̆ dozi. Materialy i metody. Za dopomogoiu oryginal'nogo metodu kul'tyvuvannia u gelevykh dyfuziy̆nykh kamerakh in vivo klityn kistkovogo mozku myshey̆ Balb/C bulo doslidzheno efektyvnist' koloniieutvorennia gemopoetychnykh klityn- poperednykiv tvaryn, iakykh bulo piddano diï ionizuiuchoï radiatsiï u subletal'niy̆ dozi, za umov zastosuvannia roz- chynu melaninovykh pigmentiv bazydiomitsetovykh grybiv u iakosti radioprotektora.Rezul'taty ta vysnovky. Doslidzhennia funktsional'noï aktyvnosti klityn-poperednykiv kistkovogo mozku op- rominenykh myshey̆ Balb/C dozvolylo otsinyty stan krovotvorennia za umov diï ionizuiuchoï radiatsiï ta pry pope- redniy̆ obrobtsi tvaryn rozchynom melaninovykh pigmentiv u iakosti radioprotektora. Bulo z’iasovano, shcho pid vply- vom ionizuiuchogo vyprominiuvannia znyzhuvalasia koloniieutvoriuiucha aktyvnist' kistkovogo mozku myshey̆ porivnia- no z kontrolem. Rozchyn melaninovykh pigmentiv buv zdatnym pidvyshchuvaty funktsional'nu aktyvnist' kistkovogo mozku oprominenykh tvaryn. Otrymani rezul'taty radioprotektornoï diï rozchynu melaninovykh pigmentiv ba- zydiomitsetiv na opromineni stovburovi klityny ta ïkh nashchadky (klityny-poperednyky) mozhut' buty pidґruntiam dlia rozrobky zasobiv zakhystu organizmu liudyny vid poshkodzhuiuchoï diï ionizuiuchoï radiatsiï.
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