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  • Title: ANALYSIS OF STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE THYROID GLAND IN PATIENTS WITH MALIGNANT BREAST TUMORS, WHO SUFFERED FROM THE CHORNOBYL ACCIDENT.
    Author: Basyka DA, Lytvynenko OO, Bugaicov SG, Shakhrai GF, Daniluk II.
    Journal: Probl Radiac Med Radiobiol; 2019 Dec; 24():312-321. PubMed ID: 31841476.
    Abstract:
    OBJECTIVE: Study the nature of structural and functional changes in the thyroid gland in patients with malignant tumors of the mammary glands that have suffered from the Chornobyl accident. MATERIALS AND METHODS: Examination of 80 patients with malignant tumors of the mammary glands at the age of 27-85 years. In 78 patients were diagnosed with breast cancer with different stages of the spread of the tumor process. The participants in the aftermath of the accident were 12 people, living in radioactive contaminated areas - 68. Mammography was performed with the help of mammographs Senographe 700 T and 800 Tsm. Echo- graphic study of the structure of the mammary gland and the thyroid gland was performed on the ultrasound devices Nemio XG SSA-580. Computed tomography was performed on a multi-detector computed tomography 64 КТ «LightSpeed VCT». MRI was performed on a magnetic resonance imager «Magnetom Vision Plus 1,5 T». For trepan biopsies, special needles were used in combination with a biopsy system gun «Magnum». The functional state of the thyroid gland was studied by studying the level of the thyroid hormone in peripheral venous blood. RESULTS: The results of the ultrasound study on the structural changes in the thyroid gland (TG) and markers that characterize the functional state of the TG in women with breast cancer, show that 60 out of 80 patients who asked for help with various forms of breast cancer and examined in the clinic, revealed the presence of structural changes in the thyroid gland, which is 75 %.Сonclusions. Structural changes in the thyroid gland in patients with breast cancer, who are considered victims of the Chornobyl Nuclear Power Plant accident, were diagnosed in 75 %, of which 71.25 % of patients did not know about the presence of pathological changes in the thyroid gland before the examination in the clinic. In the struc- ture of the identified pathological changes in the thyroid gland, 47.5 % accounted for the nodular goiter, 10 % for small hydrophilic and small fibrous areas, 3.75 % for previously undergone surgery for thyroid removal, 3.75 % for chronic thyroiditis, 7.5 % - CAIT, 2.5 % - cystic changes in the thyroid gland, 3.75 % - nodular goiter and CAIT. Meta: vyvchennia kharakteru strukturnykh i funktsional'nykh zmin u shchytopodibniy̆ zalozi u khvorykh zi zloiakisnymy novoutvorenniamy molochnykh zaloz, iaki postrazhdaly vid avariï na ChAES.Material ta metody. Obstezheno 80 patsiientok zi zloiakisnymy novoutvorenniamy molochnykh zaloz vikom 27–85 rokiv. U 78 khvorykh diagnostovano rak molochnoï zalozy (RMZ) z riznymy stadiiamy rozpovsiudzhenosti pukhlynnogo protsesu. Uchasnyts' likvidatsiï naslidkiv avariï bulo 12 osib, meshkanok radiatsiy̆no-zabrudnenykh terytoriy̆ – 68. Mamografiiu vykonuvaly za dopomogoiu mamografiv Senographe 700 T and 800 Tsm (firma GE Medical Systems). Ekhografichne doslidzhennia struktury molochnykh i shchytopodibnykh zaloz provodyly na UZ-aparatakh Nemio XG SSA-580. Komp’iuternu tomografiiu vykonuvaly na mul'tydetektornomu komp’iuternomu tomografi 64 KT «LightSpeed VCT», MRT – na magnitno-rezonansnomu tomografi «Magnetom Vision Plus 1,5 T». Dlia trepanobiopsiï zastosovuvaly spetsial'ni golky v kompleksi z biopsiy̆nym pistoletom systemy «Magnum». Vyvchaly funktsional'nyy̆ stan shchyto- podibnoï zalozy shliakhom vyvchennia rivnia tyreoïdnykh gormoniv v peryferychniy̆ venozniy̆ krovi.Rezul'taty. Rezul'taty provedenogo UZ-doslidzhennia shchytopodibnykh zaloz (ShchZ) ta markeriv, iaki kharakteryzuiut' ïkh funktsional'nyy̆ stan u zhinok, khvorykh na RMZ, svidchat', shcho u 60 patsiientok iz 80, iaki zvernulysia za dopomogoiu z pryvodu riznykh form RMZ ta buly obstezheni v umovakh kliniky, vyiavleno naiavnist' strukturnykh zmin v ShchZ, shcho stanovyt' 75 %.Vysnovky. Strukturni zminy v shchytopodibniy̆ zalozi u patsiientok, khvorykh na RMZ, iaki vvazhaiut'sia poterpilymy vid avariï na ChAES, diagnostovano u 75 % vypadkiv, iz nykh do obstezhennia v umovakh kliniky 71,25 % patsiientok ranishe ne znaly pro naiavnist' patologichnykh zmin v shchytopodibniy̆ zalozi. U strukturi vyiavlenykh patologichnykh zmin v shchy- topodibniy̆ zalozi 47,5 % stanovyt' vuzlovyy̆ zob, 10 % – dribni gidrofil'ni ta dribni fibrozno zmineni dilianky, 3,75 % – ranishe pereneseni operatyvni vtruchannia z pryvodu vydalennia shchytopodibnoï zalozy, 3,75 % – khronich- nyy̆ tyreoïdyt, 7,5 % – khronichnyy̆ autoimunnyy̆ tyreoïdyt, 2,5 % – kistozni zminy u shchytopodibniy̆ zalozi, 3,75 % – vuzlovyy̆ zob i khronichnyy̆ autoimunnyy̆ tyreoïdyt.
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