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  • Title: COMPARATIVE CHARACTERISTICS OF SPERMOGRAPHIC INDICATORS IN IDIOPATHIC FORMS OF INFERTILITY IN MEN FROM RADIOACTIVELY CONTAMINATED AND CONVENTIONALLY CLEAN REGIONS OF UKRAINE.
    Author: Gorpynchenko I, Gurzhenko Y, Spyrydonenko V, Lytvinets E.
    Journal: Probl Radiac Med Radiobiol; 2019 Dec; 24():367-379. PubMed ID: 31841480.
    Abstract:
    OBJECTIVE: the compare of men reproductive function with idiopathic infertility on the grounds of spermogram tests from the radioactively contaminated and conventionally clean regions of Ukraine. MATERIALS AND METHODS: There are 143 men (group I) with idiopathic infertility in the form of asthenozoospermia of the II degree living in the territories of the Kyiv region were investigated in the Department of Sexual Pathology and Andrology of the SI «Institute of Urology of the National Academy of Medical Sciences of Ukraine» and exposed to ionizing radiation due to the Chornobyl accident in 1986. All individuals in the I group were born from parents who were in the accident at the Chornobyl Nuclear Power Plant in the area of radioactive contamination and perma- nently resided in areas with a high level of radioactivity. The control group was made up of persons born and living in the Ivano-Frankivsk region with a similar with a similar state of health (group II, n = 157). The mean age of the studied group I was (28.3 ± 2.4) years, and persons of the II group were (30.1 ± 2.8) years. Diagnosis of II was per- formed ambulatory in accordance with WHO and Ministry of Health of Ukraine standards. The research was to study and compare spermogram parameters in patients from both groups. RESULTS: It has been established that the reproductive problems of men with idiopathic infertility living in radia- tively contaminated areas of the Kyiv region of Ukraine consist in a significant violation of the quality indicators of ejaculate (mobility by the pool A+B is less than 1.6 times, р < 0.05) correlating with modifications of physicochemi- cals (the average time of liquefaction is 1.4 times greater, р < 0.05) and biochemical (decrease of levels of fructose by 2.2 times, citrate - by 1.6 times, р < 0.001-0.05) investigation. CONCLUSIONS: The study found that the level of general indicators of spermogram is significantly worse in the regions of Ukraine who were exposed to radioactive contamination due to the Chornobyl accident, in contrast to the indicators of persons from conventionally clean regions. Meta: porivniaty reproduktyvnu funktsiiu u cholovikiv z idiopatychnym bezpliddiam na osnovi pokaznykiv spermo- gramy z radiatsiy̆no zabrudnenykh ta umovno chystykh regioniv Ukraïny.Materialy i metody. U viddili seksopatologiï ta andrologiï DU «Instytut urologiï NAMN Ukraïny» bulo provede- no doslidzhennia reproduktyvnoï funktsiï u 143 osib (I grupa) z idiopatychnym bezpliddiam u vygliadi astenozoos- permiï II stupenia, iaki meshkaiut' na terytoriiakh Kyïvs'koï oblasti (Polis'kogo, Chornobyl's'kogo, Ivankivs'kogo, Borodians'kogo, Vyshgorods'kogo ray̆oniv) ta zaznaly vplyvu ionizuiuchoï radiatsiï vnaslidok avariï na ChAES u 1986 rotsi. Usi osoby I grupy buly narodzheni vid bat'kiv, iaki znakhodylysia pid chas avariï na ChAES v zoni radiatsiy̆nogo zabrudnennia ta postiy̆no prozhyvaly na terytoriï z pidvyshchenym radioaktyvnym fonom. Grupu kontroliu sklaly osoby, iaki narodylysia ta meshkaly na terytoriï Ivano-Frankivs'koï oblasti, z analogichnym stanom zdorov’ia (II grupa, n = 157). Seredniy̆ vik obstezhenykh osib I grupy stanovyv (28,3 ± 2,4) rokiv, II grupy – (30,1 ± 2,8) rokiv. Diagnostyka idiopatychnogo bezpliddia provodylasia na ambulatornomu etapi zgidno zi standartamy VOOZ ta MOZ Ukraïny. Doslidzhennia poliagalo u vyvchenni i porivnianni pokaznykiv spermogramy u patsiientiv obokh grup. Rezul'taty. Reproduktyvni problemy u cholovikiv z idiopatychnym bezpliddiam, iaki meshkaiut' u radiatsiy̆no zabrud- nenykh ray̆onakh Kyïvs'koï oblasti Ukraïny poliagaiut' v dostovirnomu porushenni iakisnykh pokaznykiv eiakuliatu (rukhlyvist' spermatozoïdiv za danymy pulu A + V ie menshoiu u 1,6 raza; r < 0,05), shcho koreliuiut' z modyfikatsiiamy fizyko-khimichnykh (seredniy̆ pokaznyk chasu rozridzhennia bil'shyy̆ u 1,4 raza; r < 0,05) i biokhimichnykh (znyzhennia rivniv fruktozy u 2,2 raza, tsytratu – v 1,6 raza; r < 0,001–0,05) danykh.Vysnovky. Vstanovleno, shcho riven' zagal'nykh pokaznykiv spermogramy ie dostovirno girshym u regionakh Ukraïny, iaki zaznaly radioaktyvnogo zabrudnennia pid chas avariï na ChAES, na vidminu vid pokaznykiv osib z umovno chystykh regioniv.
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