These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [HYPERPARATHYROIDISM AND PARATHYROID LESIONS IN THE ChNPP ACCIDENT SURVIVORS].
    Author: Kaminskyi OV, Kopylova OV, Afanasyev DE, Loganovsky KM, Talko VV, Muraveva IM, Chikalova IG, Tepla OV, Kiseliova IO, Bryliova NV, Gryschenko KO, Tsvet LO, Pleskach OY.
    Journal: Probl Radiac Med Radiobiol; 2019 Dec; 24():380-394. PubMed ID: 31841481.
    Abstract:
    OBJECTIVE: Study of the status of parathyroid glands in individuals exposed to ionizing radiation as a result of the ChNPP accident and comparison with the general population of Ukraine. MATERIALS AND METHODS: Subjects exposed as a result of the ChNPP accident (n = 1,348) and people from the general population of Ukraine (n=655) were examined. Diagnostic ultrasound scan of thyroid and parathyroid glands (PTG) was conducted in all study subjects. The technique of parathyroid ultrasound screening was developed, which led to an increase in the efficiency of their imaging. Additionally, the 25-hydroxyvitamin D (25(OH)D), parathyroid hor- mone, ionized calcium and some other parameters were selectively assayed in serum. RESULTS: High incidence of parathyroid hyperplasia was detected 27-32 years after the irradiation in persons ex- posed as a result of the ChNPP accident, especially in evacuees from the 30-km exclusion zone (71.4%; χ2Yates' = 24.1; р = 0) and residents of radilogically contaminated territories (41.7%; χ2Yates' = 6.45; p < 0.01) having no primary hyperparathyroidism. High prevalence of vitamin D insufficiency and deficiency was revealed in all study subgroups, namely in 83.1 % of the general population of Ukraine along with a bit better vitamin D status in the ChNPP acci- dent survivors i.e. the vitamin insufficiency and deficiency was found in 78.7 % of them. Incidence of hyperparathy- roidism, predominantly of the secondary (normocalcemic) one, was 33.8 % among persons exposed as a result of the ChNPP accident (p > 0.3) being somewhat higher than in the general population of Ukraine (26.1%), despite above- mentioned better supply of vitamin D. CONCLUSIONS: There is a widespread insufficiency or deficiency of vitamin D (over 78.7%) in the population of Ukraine in general providing an unfavorable background for the higher prevalence of health disorders associated with calcium and phosphorus metabolism. The latter features parathyroid hyperplasia and musculosceletal, immune, cardiovascular, and endocrine system comorbidities. Such disorders should exacerbate with a secondary increase in parathyroid hormone secretion (26.1 %). Higher incidence of normocalcemic hyperparathyroidism (33.8% versus 26.1%) against a background of better vitamin D status among irradiated individuals indicates the existence of other factors, where the past combined effects of Chornobyl radioactive fallout and external parathyroid exposure are most likely to be involved. This could explain the greater number of cases of parathyroid hyperplasia and hyper- parathyroidism among the exposed subjects. However the additional precise studies are required here with clarifi- cation of the personal data in population groups of the ChNPP accident survivors. Participants of the ChNPP acci- dent clean-up work in the «iodine period» of 1986 are of especial concern here. Besides that, the study population should be expanded with inclusion of subjects exposed in prenatal period. Meta: doslidyty stan pryshchytopodibnykh zaloz u osib, iaki zaznaly oprominennia vnaslidok avariï na ChAES, porivniaty iz zagal'noiu populiatsiieiu meshkantsiv Ukraïny.Materialy ta metody. Namy bulo obstezheno 1348 osib, oprominenykh vnaslidok avariï na ChAES, ta 655 osib iz za- gal'noï populiatsiï meshkantsiv Ukraïny. Vsim patsiientam bulo provedeno ul'trazvukove doslidzhennia shchytopodibnoï ta pryshchytopodibnykh zaloz (PShchZ). Bula vidprats'ovana metodyka skryningovogo ul'trazvukovogo doslidzhennia PShchZ, shcho pryzvelo do pidvyshchennia efektyvnosti ïkh vizualizatsiï. Dodatkovo provodylos' vybirkove doslidzhennia rivnia 25-gidroksyvitaminu D (25(ON)D), paratgormonu ta ionizovanogo kal'tsiiu u syrovattsi krovi, deiakykh inshykh pokaznykiv.Rezul'taty. Cherez 27–32 roky pislia oprominennia vyiavleno vysoku chastotu giperplaziy̆ PShchZ u osib, opromine- nykh vnaslidok avariï na ChAES, peredusim v evakuy̆ovanykh z 30-kilometrovoï zony vidchuzhennia (71,4 %; χ2Iatsa = 24,1; r = 0) i meshkantsiv radioaktyvno zabrudnenykh terytoriy̆ (41,7 %; χ2Iatsa= 6,45; r < 0,01) bez pervynnogo giperpa- ratyreozu. Vstanovleno vysoku poshyrenist' nestachi/defitsytu vitaminu D v usikh grupakh doslidzhennia: sered osib iz zagal'noï populiatsiï meshkantsiv Ukraïny – 83,1 %, ta deshcho krashchyy̆ status za vitaminom D v osib, postrazhdalykh vnaslidok avariï na ChAES (78,7 %). Chastota giperparatyreozu, perevazhno vtorynnogo (normokal'tsiiemichnogo), stanovyla 33,8 % sered osib, oprominenykh vnaslidok avariï na ChAES (r > 0,3), i bula deshcho vyshchoiu, nizh v zagal'niy̆ populiatsiï ukraïntsiv (26,1 %), nezvazhaiuchy na krashchu zabezpechenist' vitaminom D.Vysnovky. Zagalom naselennia Ukraïny maie poshyrenu nestachu/defitsyt vitaminu D (ponad 78,7 %), shcho stvoriuie negatyvnu bazu dlia bil'shogo poshyrennia porushen' zdorov’ia, pov’iazanykh z dysfunktsiiamy kal'tsiievo-fosfornogo obminu u vygliadi giperplaziï PShchZ i komorbidnykh staniv z boku oporno-rukhovogo aparatu, imunnoï, sertsevo-sudyn- noï, endokrynnoï system. Taki zminy povynni posyliuvatysia pry vtorynnomu zbil'shenni sekretsiï paratgormonu (26,1 %). Bil'sha chastota normokal'tsiiemichnykh giperparatyreoziv (33,8 % proty 26,1 %) na tli krashchoï zabezpeche- nosti vitaminom D sered oprominenykh osib, svidchyt' pro isnuvannia inshykh chynnykiv, do iakykh z nay̆bil'shoiu virogidnistiu mozhna vidnesty mynulyy̆ kombinovanyy̆ vplyv radionuklidiv avariy̆nogo chornobyl's'kogo vykydu i zovnishnie oprominennia PShchZ. Tse moglo b poiasnyty bil'shu kil'kist' giperplaziy̆ PShchZ ta giperparatyreozu sered oprominenykh, ale potrebuie provedennia dodatkovykh utochniuiuchykh doslidzhen', z detalizatsiieiu danykh za grupamy postrazhdalykh vnaslidok avariï na ChAES i obov’iazkovym vydilenniam uchasnykiv likvidatsiï naslidkiv avariï na ChAES y̆odnogo periodu 1986 r. ta rozshyrenniam kil'kosti obstezhenykh osib, oprominenykh vnutrishn'outrobno.
    [Abstract] [Full Text] [Related] [New Search]