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  • Title: LUNG FUNCTION AND TELOMERE RELATIVE LENGTH IN CLEAN-UP WORKERS OF CHORNOBYL NPP ACCIDENT IN A REMOTE POST-ACCIDENT PERIOD.
    Author: Shvaiko LI, Bazyka KD, Sushko VO, Ilienko IM, Bazyka DA.
    Journal: Probl Radiac Med Radiobiol; 2019 Dec; 24():503-515. PubMed ID: 31841491.
    Abstract:
    OBJECTIVE: The objective was to study the relationship between functional status of bronchopulmonary system and telomere length in clean-up workers of Chornobyl NPP accident in a remote post-accident period. MATERIALS AND METHODS: A study was performed in 113 clean-up workers of Chornobyl NPP accident. Individual do- cumented doses of irradiation in clean-up workers ranged from 1,0 to 880 mSv (330.4 ± 317.7 (M ± SD)). The aver- age age of the Chornobyl NPP participants was (62.21 ± 6.99) years. A complex of functional pulmonary tests (spirometry, body plethysmography, examination of lung diffusion capacity) was performed. Relative telomere length (RTL) was analysed by flow-FISH. RESULTS: There was a tendency to decrease the relative telomere length in clean-up workers with COPD I-II stage and COPD III-IV, compared with patients with the absence of bronchopulmonary diseases (RTL 15,2 ± 2,7). Significantly shorter telomeres were observed in patients with COPD who were exposed to radiation at a dose of more than 500 mSv (13.6 ± 2.5) compared with COPD patients who were exposed at a dose <10 mSv (RTL 15.3 ± 2.3). When analyzing the correlation relationships of the studied indicators, no significant associations were found with the relative telomere length. At this stage of the study no association of relative telomere length with age, body mass index, and functional criteria (FEV1 (l), intrathoracic pressure (ITGV), total lung capacity (TLC), diffusion lung capac- ity (DLCO)) was detected. CONCLUSIONS: The analyzed telomere length relationship from liquidators of the Chernobyl found no direct associa- tion with indicators of lung function tests, however, showed a trend towards reducing the relative telomere length in clean-up workers who suffer from COPD and exposed to doses from 100 to 500 mSv and above 500 mSv. Meta: vyvchyty vzaiemozv’iazok mizh funktsional'nym stanom bronkholegenevoï systemy ta dovzhynoiu telomer v uchasnykiv likvidatsiï naslidkiv avariï (ULNA) na ChAES u viddalenomu pisliaavariy̆nomu periodi.Materialy ta metody. Obstezheno 113 ULNA na ChAES (ULNA) 1986–1987 rr. cholovichoï stati. Indyvidual'ni zado- kumentovani dozy radiatsiy̆nogo oprominennia ULNA stanovyly vid 1,0 do 880 mZv (330,4 ± 317,7 (M ± SD)). Se- redniy̆ vik patsiientiv skladav (62,21 ± 6,99) rokiv. Provedeno kompleks funktsional'nykh legenevykh testiv (spiro- metriia, bodipletyzmografiia, doslidzhennia dyfuziy̆noï zdatnosti legen'). Vidnosnu dovzhynu telomer vyznachaly metodom flow-FISH.Rezul'taty. Vyiavlena tendentsiia do skorochennia vidnosnoï dovzhyny telomer v ULNA, iaki khvoriiut' na KhOZL I–II stadiï ta KhOZL III–IV stadiï, porivniano z ULNA, iaki ne maly zakhvoriuvan' bronkholegenevoï systemy (15,2 ± 2,7). Dostovirno korotshi telomery sposterigalys' u khvorykh na KhOZL, iaki zaznaly diï oprominennia u dozi ponad 500 mZv (RTL 13,6 ± 2,5) porivniano z khvorymy na KhOZL, kotri buly opromineni u dozi menshe 100 mZv (RTL 15,3 ± 2,3). Pry koreliatsiy̆nomu analizi doslidzhuvanykh funktsional'nykh pokaznykiv (FEV1 (l), vnutrishn'ogrudnogo tysku (ITGV), zagal'noï iemnosti legen' (TLC) dyfuziy̆noï zdatnosti legen' (DLCO) z vidnosnoiu dovzhynoiu telomer dos- tovirnykh asotsiatsiï vyiavleno ne bulo. Na danomu etapi takozh ne vyiavleno bud'-iakoï asotsiatsiï vidnosnoï dovzhy- ny telomer iz vikom ta indeksom masy tila.Vysnovky. Na danomu etapi doslidzhen' ne vstanovleno vzaiemozv’iazku dovzhyny telomer z pokaznykamy funk- tsional'nykh legenevykh testiv v ULNA na ChAES. Pry ts'omu vyiavlena tendentsiia do skorochennia vidnosnoï dovzhyny telomer v ULNA, kotri khvoriiut' na KhOZL ta zaznaly diï ionizuiuchogo oprominennia v dozakh vid 100 do 500 mZv ta ponad 500 mZv.
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