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  • Title: Measurement of serum levels of oestriol and human placental lactogen in the management of pre-eclamptic pregnancies.
    Author: Isouard G.
    Journal: Med J Aust; 1979 Oct 20; 2(8):401-4. PubMed ID: 318463.
    Abstract:
    Maternal serum levels of total oestriol and human placental lactogen (HPL) were measured in 280 normal and 87 pre-eclamptic pregnancies. Normal levels of HPL, but significantly reduced total oestriol values were obtained when pre-eclampsia was present. However, when fetal complications developed, both hormone levels were further significantly reduced. The severity of pre-eclampsia had no effect on the serum levels of oestriol and HPL. An analysis of the 18 pregnancies with significant fetal-placental dysfunction showed that 13 (72%) were predicted by unfavourable levels of total oestriol, nine (50%) by unfavourable levels of HPL, and 14 (78%) by the use of both assays. The present study supports the value of antenatal measurement both of serum total oestriol and of HPL in the management of pre-eclamptic pregnancies.
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