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  • Title: [Oxygen--concentration and acid-base status of arterial blood as limiting factors in hemodilution].
    Author: Zander R.
    Journal: Klin Wochenschr; 1988; 66 Suppl 15():3-7. PubMed ID: 3184785.
    Abstract:
    Normovolemic hemodilution under normoxic conditions (arterial oxygen partial pressure normal) at rest is limited by the critical arterial oxygen content of about 6 ml/dl corresponding to a hemoglobin concentration of 4.4 g/dl. This critical oxygen content is derived from the arteriovenous oxygen difference of the myocardium, assumed that the coronary blood flow is increased by 100% and the available oxygen is utilized nearly totally. Furthermore, extreme hemodilution leads to a dilution acidosis when bicarbonate free solutions are used for hemodilution. This acidosis may decrease both peripheral resistance and mean arterial blood pressure.
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