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  • Title: Relationship between extraluminal oxyhemoglobin and endothelium-dependent vasodilatation in isolated perfused canine internal carotid arteries.
    Author: Tanaka Y, Chiba S.
    Journal: Neurosurgery; 1988 Aug; 23(2):158-61. PubMed ID: 3185874.
    Abstract:
    The stainless steel cannula insertion method was applied to investigate the endothelium-dependent relaxation of canine intracranial internal carotid arteries. The arteries were precontracted by extraluminally administrated 0.67 X 10(-4) M 5-hydroxytryptamine or 10(-5) M oxyhemoglobin (oxyHb). There was no significant difference between these groups in the dose-response curves of acetylcholine (ACh)-induced relaxation. The concentration of oxyHb used was enough to abolish the endothelium-dependent relaxation by ACh when administered intraluminally in this preparation. The blocking effect of oxyHb to endothelium-derived relaxing factor (EDRF) did not appear for at least 3 hours after the extraluminal application of 10(-5) M oxyHb. These results suggest that the inactivation of EDRF by oxyHb may not play an important role in producing cerebral vasospasm in the initial stage after subarachnoid hemorrhage.
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