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  • Title: The effect of respiratory carcinogenesis on systemic humoral and cell-mediated immunity of Syrian golden hamsters.
    Author: Zwilling BS.
    Journal: Cancer Res; 1977 Jan; 37(1):250-2. PubMed ID: 318605.
    Abstract:
    The effect of intratracheal instillation of benzo(a)pyrene and its noncarcinogenic analog benzo(a)pyrene on the systemic humoral and cell-mediated immune response of Syrian golden hamsters was evaluated. Hamsters treated with the carcinogen had a transient suppression of the splenic plaque-forming cell response to sheep erythrocytes, compared with analog-treated controls. The numbers of direct (immunoglobulin M) and indirect (immunoglobulin G) plaque-forming cells were suppressed at the 9th week of treatment and then recovered to control levels. No suppression in the cell-mediated immune response, as assessed by the rejection of Chinese hamster skin grafts, was found.
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