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  • Title: Phenylethyl isothiocyanate induces oxidative damage of porcine kidney cells mediated by reactive oxygen species.
    Author: Zhu Y, Liu S, Yan S, Wang J, Zhang L, Li X, Wen L, Wu J.
    Journal: J Biochem Mol Toxicol; 2020 Feb; 34(2):e22428. PubMed ID: 31860765.
    Abstract:
    The aim of this study is to confirm the toxic effect of phenylethyl isothiocyanate (PEITC) on porcine kidney cells (PK-15) and explore the effect of oxidative damage mediated by reactive oxygen species (ROS) induced by PEITC in PK-15 cells. Porcine kidney cell line (PK-15) was treated with PEITC (2, 5, and 10  µM) for 24 hours, and the oxidative damage mediated by PEITC through ROS was investigated. The survival rate of PK-15 cells decreased in a dose-dependent manner after the treatment of PEITC in a dose-dependent manner. A high concentration of PEITC (10 µM) can change cell morphology, increase the content of malondialdehyde, ROS, and lactate dehydrogenase, and decrease the activity of SOD, CAT, GSH-PX, and GSH. PEITC has a toxic effect on PK-15 cells by inducing oxidative stress in PK-15 cells through the generation of ROS.
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