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  • Title: Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide.
    Author: Ramesh KS, Rao NA.
    Journal: Biochem J; 1978 Sep 15; 174(3):1055-8. PubMed ID: 31864.
    Abstract:
    The positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with NADH and NADPH. NAD+ was a negative heterotropic effector, whereas NADP+ was without effect. The allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes.
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