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  • Title: [Resuscitation of severe meningitis in infants and children].
    Author: Floret D.
    Journal: Pediatrie; 1988; 43(6):477-85. PubMed ID: 3186420.
    Abstract:
    Meningeal penetration of bacteria induces an inflammatory response which affects mainly the endothelium of cerebral vessels. This inflammatory reaction is directly responsible for thrombosis and indirectly creates cerebral oedema and reduced cerebral blood flow. Cerebral ischemia is the result of all these phenomenons. Nowadays, control of cerebral oedema is the main goal of intensive care treatment of meningitis that needs invasive monitoring of intracranial pressure. We may hope that in a next future new therapeutic agents will be able to control inflammatory reaction and vascular process.
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