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  • Title: Purification of the human placental NAD-linked 15-hydroxyprostaglandin dehydrogenase.
    Author: Jarabak J, Watkins JD.
    Journal: Prostaglandins; 1988 Aug; 36(2):205-13. PubMed ID: 3187061.
    Abstract:
    An NAD-linked 15-hydroxyprostaglandin dehydrogenase has been purified 13,100-fold from human placental tissue. The specific activity of the purified enzyme ranges from 6900 to 8300 mU/mg protein depending on the method used to determine the protein concentration. On discontinuous electrophoresis in sodium dodecyl sulfate more than 95% of the protein migrates as a single band; its estimated molecular weight is 25.5-26.0 kDa. This is half the value obtained when the molecular weight is estimated under non-denaturing conditions and suggests that the enzyme is composed of two identical or nearly identical subunits.
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