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  • Title: Lipid and poly (ethylene glycol)-conjugated bi-functionalized chlorine e6 micelles for NIR-light induced photodynamic therapy.
    Author: Muddineti OS, Kiran Rompicharla SV, Kumari P, Bhatt H, Ghosh B, Biswas S.
    Journal: Photodiagnosis Photodyn Ther; 2020 Mar; 29():101633. PubMed ID: 31870896.
    Abstract:
    BACKGROUND: To develop a photosensitizer, chlorin e6 (Ce6)-based amphiphilic polymer, DP-Ce6, where DOPE and PEG are conjugated to Ce6, which would self-assemble to form polymeric micelles (DP-Ce6-M) in aqueous environment. METHODS: DP-Ce6-M were characterized for particle size, zeta potential, and singlet oxygen (1O2) generation. Cellular internalization, phototoxicity were investigated against monolayer and 3D spheroids of human lung adenocarcinoma cells (A549). RESULTS AND CONCLUSIONS: DP-Ce6-M formed stable micelles with particles size of 58.2 ± 1.6 nm. Solubility of Ce6 was improved. Photoactivity of DP-Ce6-M was sustained in regard to 1O2 generation compared to free Ce6. The DP-Ce6-M showed enhanced internalization and growth inhibition in monolayer and spheroidal cells. Overall, DP-Ce6-M demonstrated the potential for further exploration as PDT agent for cancer treatment.
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