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  • Title: Effects of intravenous bolus dosages of methylprednisolone and local radiation on renal allograft rejection and patient mortality.
    Author: Nakajima N, Sreepada Rao TK, Sakai A, Butt KH, Kountz SL.
    Journal: Surg Gynecol Obstet; 1977 Jan; 144(1):63-6. PubMed ID: 318773.
    Abstract:
    One hundred and thirty of 179 rejection episodes encountered in 205 transplants were reversed by treatment with a bolus preparation of methylprednisolone. Ninety-six of these episodes also required an increase in oral prednisone dosage. No beneficial effect on over-all graft survival was noted, but a significant rise in the mortality, secondary to sepsis, was noted in those who received more than 5 grams of methylprednisolone. Local radiation to the graft did not contribute to better graft survival or mortality.
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