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  • Title: Knockdown RPL29 Gene Can Inhibit the Proliferation, Invasion of Squamous Cell Carcinomas.
    Author: Li J, Peng Y.
    Journal: Ann Clin Lab Sci; 2019 Nov; 49(6):763-769. PubMed ID: 31882427.
    Abstract:
    OBJECTIVE: Gingival squamous cell carcinoma (GSCC) is one of the most common malignancies. Endogenous ribosomal protein L29 (RPL29) has been previously proven to be up-regulated in cancer tissues. However, RPL29 expression in GSCC has not been described. METHODS: The knockdown of RPL29 gene in GSCC cells was carried out to study the influence of RPL29 silencing on GSCC cells. RESULTS: We investigated the influence on cell proliferation, invasion, and related biomarkers, which led us to confirm that all were repressed by the knockdown of RPL29. CONCLUSION: The role of RPL29 should lead to a better understanding of the development and progression of human GSCC.
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