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  • Title: [Acetoin metabolism in animal tissues].
    Author: Zavodnik IB, Buko VU, Ostrovskiĭ IuM.
    Journal: Ukr Biokhim Zh (1978); 1988; 60(4):58-62. PubMed ID: 3188258.
    Abstract:
    The acetoin-synthesizing activity has been studied in the skeletal muscles, brain, liver and spleen homogenates (numbered as the activity decreases). The acetoin-synthesizing activity drastically increases in case of the acetaldehyde excess and alcohol intoxication. The acetaldehyde concentrations of above 1.10(-3) M inhibit the liver pyruvate dehydrogenase activity and increase the non-oxidative transformation of pyruvate. Acetoin is rapidly metabolized in the organism eliminating from blood 10 minutes after its injection. Acetoin is an effective precursor in the biosynthesis of lipids.
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