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  • Title: Colonic Perforation in a Term Newborn with Hereditary Protein C Deficiency.
    Author: Mizumoto H, Kimura M, Hata D.
    Journal: Indian Pediatr; 2019 Dec 15; 56(12):1057-1059. PubMed ID: 31884442.
    Abstract:
    We describe a term infant who experienced recurrent apnea associated with intracranial hemorrhage and later, developed colonic perforation. Plasma protein C activity was below detectable limits and a heterozygous PROC mutation was identified. Neonatal colonic perforation is rare, and this case report highlights the importance of considering congenital Protein C deficiency.
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