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  • Title: [Effect of piracetam on the neuronal activity of the neocortex and on behavior in rabbits during learning].
    Author: Shul'gina GI, Okhotnikov NV, Ryzhov SO.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1988; 38(3):460-6. PubMed ID: 3188641.
    Abstract:
    Against the background of the action of piracetam--a cyclic derivative of GABA--in a dose of 200-400 mg/kg, no significant changes were observed of probabilities of motor reactions to inhibitory and reinforced light flashes. Piracetam in that dose did not affect inhibitory pauses in responses of neurones in the visual area and corresponding late components of the evoked potential to nonreinforced light flashes, i.e. it did not intensify inhibitory hyperpolarization processes in the cerebral cortex. Piracetam administration improved differentiation of inhibitory and reinforced light flashes judging by bioelectric parameters of the brain activity as a result of intensification of pain reinforcement action on cortical neurones. The carried-out experiments revealed significant differences in neurophysiological mechanisms of action of piracetam and fenibut--GABA linear derivate related to nootropic class.
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