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  • Title: [Reorganization of the synaptic architectonics of the cerebral cortex in antigenic sensitization of the brain and in convulsive paroxysms].
    Author: Savchenko IuN, Ereniev SI, Semchenko VV, Stepanov SS.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1988; 88(6):3-6. PubMed ID: 3188744.
    Abstract:
    In Krushinskiĭ-Molodkina rats sensibilized for 5 days with brain extract antigens (BEA) and/or subjected to repetitive seizures (S), the synaptic architectonics of the molecular layer was studied in the sensorimotor cortex preparations treated with phosphotungstic acid. Unlike the S effect, BEA-sensibilization and BEA+S action sharply reduced the number of interneuronal contacts, especially the symmetric ones, and the structure relations of the subsynaptic units system with the surrounding cytoskeleton with decrease in the number of very small, small and medium-size synapses. In any effects the major compensatory mechanism was the hypertrophy and splitting of the interneuronal contacts. Only S action resulted in the compensatory enhancement of the new synapses formation. Possible mechanisms of the "immune" lesion of the interneuronal contacts are discussed.
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