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  • Title: [Effect of L-DOPA on the function of the brain neuromediator systems].
    Author: Lovedova EL.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1988; 88(7):19-21. PubMed ID: 3188768.
    Abstract:
    L-DOPA effects on the activities of enzymes controlling the neurotransmitters utilization: monoamine oxidases (MAO) A and B and acetylcholinesterase (AChE) were demonstrated in synaptosomes and mitochondria of the cells in sensorimotor cortex and caudate nucleus. Sixty minutes after a single dose of L-DOPA the MAO and AChE activities were virtually unchanged in subfractions of both brain regions. After a prolonged (30 days) treatment (1000 mg/kg total dose) MAO B activity increased whereas the MAO B and AChE activities decreased only in cortical synaptosomes and mitochondria. The data suggest that under effect of L-DOPA a definite reciprocity arises in the neurotransmitter catabolic systems in a specific manner for each brain structure.
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