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  • Title: [Decreased capacity of the peripheral blood lymphocytes for excisional DNA repair in disseminated sclerosis].
    Author: Moskaleva EIu, Tobolov IN, Shumilov VG, Demina TL, Gorbunov EF.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1988; 88(7):87-8. PubMed ID: 3188782.
    Abstract:
    In patients with multiple sclerosis the reduction of DNA excision reparation capacity of peripheral blood lymphocytes was found to correlate with the disease severity but not with its duration. These changes and the increase in the DNA reparative synthesis along with the lymphocytes DNA structural changes are considered as the evidence of impaired lymphocytes genome stability in this ailment. Their possible role in the development of immunodeficiency in multiple sclerosis is discussed.
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