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  • Title: Adrenal pheochromocytoma-ganglioneuroma producing catecholamines and various neuropeptides.
    Author: Salmi J, Pelto-Huikko M, Auvinen O, Karvonen AL, Saaristo J, Paronen I, Pöyhönen L, Seppänen S.
    Journal: Acta Med Scand; 1988; 224(4):403-8. PubMed ID: 3188992.
    Abstract:
    A 65-year-old woman presenting with back pain, difficulties in walking and watery diarrhea. A right adrenal tumor and high excretion of catecholamines were found. Laboratory examinations showed raised levels of vasoactive intestinal polypeptide, pancreatic polypeptide, gastrin and calcitonin. Histology showed a combined pheochromocytoma-ganglioneuroma. The neoplastic cell population was immunohistochemically shown to contain tyrosine hydroxylase, neuropeptide Y, met-enkephalin, substance P, vasoactive intestinal polypeptide, calcitonin and calcitonin gene-related peptide. Postoperatively, the patient recovered fully and the hormone levels returned to normal.
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