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  • Title: Rational modulation of coumarin-hemicyanine platform based on OH substitution for higher selective detection of hypochlorite.
    Author: Lan JS, Liu L, Zeng RF, Qin YH, Liu Y, Jiang XY, Aihemaiti A, Ding Y, Zhang T, Ho RJY.
    Journal: Chem Commun (Camb); 2020 Jan 28; 56(8):1219-1222. PubMed ID: 31895373.
    Abstract:
    To monitor delicate changes of biological HOCl in vivo, a new probe (OH-substituted coumarin-hemicyanine, probe 2) was synthesized for NIR and ratiometric HOCl detection. Selectivity studies indicated that the electron-donating group (OH) substituted on the indolium moiety enhanced the selectivity to detect HOCl. With HOCl, the probe showed a ratiometric fluorescence (I500/I650) with a low detection limit (49.1 nM) and a rapid response (within 2 min). In addition, probe 2 was successfully applied to visualize exogenous and endogenous HOCl in living cells and animals and exhibited a perfect mitochondria target ability. This probe has been further studied as a potential and powerful tool to probe HOCl in arthritis models.
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