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  • Title: Topical anesthesia of the skin by liposome-encapsulated tetracaine.
    Author: Gesztes A, Mezei M.
    Journal: Anesth Analg; 1988 Nov; 67(11):1079-81. PubMed ID: 3189897.
    Abstract:
    The potential of a liposomal local anesthetic formulation to provide topical anesthesia of the intact skin was investigated. Tetracaine base 0.5% was encapsulated into multilamellar phospholipid vesicles. The topical anesthetic effects of the liposomal and a control (Pontocaine cream) preparation were evaluated by pinprick technique in adult volunteers. Liposomal tetracaine-produced anesthesia, which lasted at least 4 hours after 1 hour application under occlusion. Pontocaine cream was ineffective. The liposomal formulation appeared to be suitable to provide long lasting anesthesia of the skin with low drug concentration.
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