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  • Title: [Determining factors in the intrauterine development of twins: possible effect of gestational age, sex and type of twins].
    Author: Ramos-Arroyo MA, Rodríguez-Pinilla E, Marcos Herrero F, Martínez Frías ML.
    Journal: An Esp Pediatr; 1988 Aug; 29(2):127-31. PubMed ID: 3190017.
    Abstract:
    Authors present a study on 9,862 malformed newborns and 9,950 controls collected among 481,362 births monitored by Spanish Collaborative Study of Congenital Malformations (ECEML) from March 1976 to March 1985. Newborn twins (malformed and controls) had a significantly lower birthweight and mortality rate within first three days of life than singletons. Difference in birthweight was not dependent on gestational age. On the other hand, males and females of unlike-sexed twin pairs were heavier than males and females of like-sexed pairs, respectively. Malformation rates in twins and singletons were not significantly different; among twins, the higher figure corresponded to like-sexed pairs, and more specifically, to those in which both members of the pair were males. Possible influence of gestational age, sex and type of twinning (like or unlike sex) on the process of intrauterine development in twins, is discussed.
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