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  • Title: Humoral immunity in vaginal candidiasis.
    Author: Mathur S, Koistinen GV, Horger EO, Mahvi TA, Fudenberg HH.
    Journal: Infect Immun; 1977 Jan; 15(1):287-94. PubMed ID: 319061.
    Abstract:
    Serum antibody titers to Candida albicans were estimated in 37 women with recurrent vaginal candidiasis and in 148 normal American and Finnish subjects, using the passive-hemagglutination technique. The antibody titers ranged from 0 to 16 in normal individuals and 4 to 256 in vaginal candidiasis patients. Antibodies to C. albicans in the sera of vaginal candidiasis patients were found to be the secretory immunoglobulin A type, as determined by gel filtration and double-diffusion tests. The results were confirmed by the indir-ct fluorescent-antibody technique. Our findings suggest that, in vaginal candidiasis, the antibody response is mainly local, consisting of secretory immunoglobulin A, some of which finds its way into systemic circulation.
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