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  • Title: A retrospective study of antibodies against basement membrane antigens (type IV collagen and laminin) in patients with primary and secondary Raynaud's phenomenon.
    Author: Gabrielli A, Montroni M, Rupoli S, Caniglia ML, DeLustro F, Danieli G.
    Journal: Arthritis Rheum; 1988 Nov; 31(11):1432-6. PubMed ID: 3190785.
    Abstract:
    Antibodies against type IV collagen were detected in the sera of 21% of patients with primary Raynaud's phenomenon (PRP) and 68% of patients with systemic sclerosis. Sera from 25% of the PRP patients and 48% of systemic sclerosis patients displayed antibodies to laminin. Eighty percent of the patients with PRP and antibodies to basement membrane antigens developed additional serologic or clinical manifestations, whereas only 16% of patients with PRP and no anti-basement membrane antibodies developed such manifestations.
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