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  • Title: [Study of antibody-hapten interaction by measuring velocity of ultrasound propagation].
    Author: Shil'nikov GV, Priev AI.
    Journal: Biofizika; 1988; 33(4):572-5. PubMed ID: 3191168.
    Abstract:
    The patterns of conformational changes induced in pig antibodies to 2,4-dinitrophenyllisin on binding with hapten were investigated by precise measurements of ultrasound velocity. It was shown that upon specific binding with intact antibodies, the observed slow changes of the bulk-clustic properties of the investigated solution reflect self-association of IgG molecules. In the case of interaction of Fab-fragments with hapten no changes of the acoustic properties were found. It was assumed that self-association is related to the increase in the hydrophobicity of Fe-fragments observed upon conformational changes of IgG molecules.
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