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  • Title: Stereospecific bioactions of 5-hydroxyeicosatetraenoate.
    Author: Rossi AG, Thomas MJ, O'Flaherty JT.
    Journal: FEBS Lett; 1988 Nov 21; 240(1-2):163-6. PubMed ID: 3191990.
    Abstract:
    5(S)-Hydroxyicosatetraenoate stimulates human polymorphonuclear neutrophils (PMNs) to raise their cytosolic calcium. It also potentiates the cells' degranulation responses to platelet-activating factor and diacylglycerols. We synthesized 5(R)-hydroxyicosatetraenoate and found it to be 20-100-fold weaker than the natural isomer in these assays. Thus, the arachidonic acid metabolite activates PMNs by a stereospecific possibly receptor-mediated mechanism.
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