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  • Title: S-100b protein regulates the activity of skeletal muscle adenylate cyclase in vitro.
    Author: Fanò G, Fulle S, Della Torre G, Giambanco I, Aisa MC, Donato R, Calissano P.
    Journal: FEBS Lett; 1988 Nov 21; 240(1-2):177-80. PubMed ID: 3191991.
    Abstract:
    We have investigated the effect of the b isoform of S-100 proteins on adenylate cyclase activity of rat skeletal muscle. S-100b inhibits the adenylate cyclase activity in the presence of Mg2+ (5.0-50 mM), while it activates the same enzyme in the presence of Ca2+ (0.1-1.0 mM) dose-dependently in both cases. S-100b counteracts the stimulatory effect of NaF on adenylate cyclase in the presence of Mg2+ and the inhibitory effect of RMI 12330 A in the presence of Ca2+.
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