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  • Title: Electrocochleography During Translabyrinthine Approach for Vestibular Schwannoma Removal.
    Author: Riggs WJ, Fitzpatrick DC, Mattingly JK, Harris MS, Hiss MM, Rajkumar S, Zhan KY, Brown KD, Moberly AC, Dodson EE, Adunka OF.
    Journal: Otol Neurotol; 2020 Mar; 41(3):e369-e377. PubMed ID: 31923083.
    Abstract:
    HYPOTHESIS: Intraoperative electrocochleography (ECochG) can differentiate hair cell and neural dysfunction caused by a vestibular schwannoma (VS) and help define the site of lesion as peripheral or central to the spiral ganglion. BACKGROUND: Hearing loss in patients with a VS can be caused by both sensory (cochlear) and neural dysfunction. METHODS: Round-window ECochG using low and high-frequency tone bursts was performed in 49 subjects with a VS. Responses were analyzed for magnitude, spectrum, and shape of the time waveform. Components examined included the cochlear microphonic, auditory nerve neurophonic, compound action potential (CAP), and summating potential (SP). RESULTS: Variability in the summed response magnitudes across frequency, or "total response" (ECochG-TR), varied from 0.1 to 100 μV. Responses were larger for lower frequencies. Subjective estimates revealed a wide range of neural contributions from the auditory nerve neurophonic to low frequencies and the CAP to high frequencies. Cases with larger CAPs had smaller SPs. The correlation of ECochG-TR, with word recognition score (WRS), was moderate (r = 0.67), as well as the correlation between pure-tone averages and ECochG (r = 0.63). The cochlea remained functional in two cases of sudden sensorineural hearing loss with 0% WRS. CONCLUSION: Reduced ECochG-TR and neural activity in many cases indicates both sensory and neural deficits. Smaller SPs when CAPs are present indicate a neural contribution to the SP. Good cochlear function with 0% WRS, and cases of sudden sensorineural hearing loss with retained cochlear function, indicate retrocochlear effects, typically proximal to the spiral ganglion cells.
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