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  • Title: Luspatercept: First Approval.
    Author: Markham A.
    Journal: Drugs; 2020 Jan; 80(1):85-90. PubMed ID: 31939073.
    Abstract:
    Luspatercept (REBLOZYL®) is an erythroid maturation agent developed by Acceleron Pharma and Celgene Corporation for the treatment of anaemia associated with myelodysplastic syndromes, myelofibrosis and beta-thalassaemia. Based primarily on the results of the phase III BELIEVE trial, subcutaneous luspatercept was recently approved in the USA for the treatment of anaemia associated with beta-thalassaemia. This article summarizes the milestones in the development of luspatercept leading to this first approval.
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